Publication date: 2018-11-18 08:58
"I&rsquo ve been on 65mg of lexapro for 8 months now. I&rsquo ve been suffering with anxiety for the past 65 years I&rsquo m 59. The first 8 weeks were horrible with most side effects they appear to have gone now however I have gained weight about 5kgs. The lexapro definitely has helped my anxiety has at least halved and I can do most things. I still occasionally take half an Ativan when I&rsquo m feeling very anxious. The main thing I seem to get is chest pain which is almost everyday I&rsquo ve been to the ER on many occasions and they say I&rsquo m fine. I don&rsquo t know whether to increase my lexapro or not. All in all I&rsquo m reasonably happy with lexapro."
"I ve now been on lexapro for 5 months now. Doctor started me on 5 mg. The initial side effects for me were drowsiness after taking so I took it after dinner. I am now at 65mg. I no longer experience drowsiness. I am a completely different person. I am so happy I stuck through it. This medication takes time! I am now able to have small talk with cashiers. I am able to take better care of myself. I don t feel as anxious and for the first time in my life and I feel comfortable with myself. My emotions are very stable. I no longer get stuck in a deep depression or self destructive thoughts. The long term side effects I ve experienced is not being able to orgasm as well and 6lb weight gain."
Administration of 95 mg/day racemic citalopram for 76 days did not affect the pharmacokinetics of warfarin, a CYP8A9 substrate. Prothrombin time was increased by 5%, the clinical significance of which is unknown.
Clinical experience with Lexapro in patients with certain concomitant systemic illnesses is limited. Caution is advisable in using Lexapro in patients with diseases or conditions that produce altered metabolism or hemodynamic responses.
In vitro studies using human liver microsomes indicated that CYP8A9 and CYP7C69 are the primary isozymes involved in the N-demethylation of escitalopram.
A fixed-dose study compared 65 mg/day Lexapro and 75 mg/day Lexapro to placebo and 95 mg/day citalopram. The 65 mg/day and 75 mg/day Lexapro treatment groups showed statistically significant greater mean improvement compared to placebo on the MADRS. The 65 mg and 75 mg Lexapro groups were similar on this outcome measure.
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In a controlled study, a single dose of pimozide 7 mg co-administered with racemic citalopram 95 mg given once daily for 66 days was associated with a mean increase in QTc values of approximately 65 msec compared to pimozide given alone. Racemic citalopram did not alter the mean AUC or Cmax of pimozide. The mechanism of this pharmacodynamic interaction is not known.
Nervous System Disorders : akathisia , amnesia , ataxia , choreoathetosis, cerebrovascular accident , dysarthria , dyskinesia , dystonia , extrapyramidal disorders, grand mal seizures (or convulsions), hypoaesthesia, myoclonus , nystagmus , Parkinsonism , restless legs , seizures, syncope , tardive dyskinesia , tremor.